Hydroxyapatite Market to Hit USD 4.45 Billion by 2032, Driven by Rising Demand in Orthopedic and Dental Applications, Sustainability Efforts, and Nano-Innovation | Research by SNS Insider

Austin, May 01, 2025 (GLOBE NEWSWIRE) -- The Hydroxyapatite Market Size was valued at USD 2.45 Billion in 2023 and is expected to reach USD 4.45 Billion by 2032, growing at a CAGR of 6.85% over the forecast period of 2024-2032.

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Surging Demand for Bio-Compatible Solutions Fuels Hydroxyapatite Integration Across Medical, Dental, and Cosmetic Industries Globally

Hydroxyapatite, a calcium-rich mineral, is rapidly being adopted across orthopedics, dental care, cosmetics, and nutritional supplements due to its bioactivity, safety, and compatibility with human tissue. The U.S. FDA recognizes it for bone graft and dental applications, while the American Dental Association in 2022 noted rising use of hydroxyapatite toothpaste as a fluoride-free remineralizing agent. Industry players like Fluidinova and Berkeley Advanced Biomaterials are scaling up nano-hydroxyapatite production to meet growing demand. In 2023, Berkeley expanded its bone graft offerings amid increased surgeries in the U.S. and Europe. L’Oréal’s 2023 report also cited R&D focus on hydroxyapatite-enriched skincare, leveraging its bio-affinity. These shifts underscore hydroxyapatite’s growing value across sectors, supported by consumer trends favoring natural, scientifically backed alternatives and technological advances in regenerative medicine.

The US Hydroxyapatite Market Size was valued at USD 540 Million in 2023 with a significant growth rate.

The U.S. Hydroxyapatite Market is witnessing robust growth, driven by its rising use in orthopedic and dental implants, and increasing demand for fluoride-free oral care. The American Academy of Orthopaedic Surgeons (AAOS) reported a 12% increase in joint replacement surgeries using bioactive materials in 2023. Major U.S.-based manufacturers are scaling production of nano-hydroxyapatite for premium dental pastes and bone scaffolds, reflecting increased medical acceptance.

Key Players:

• Cam Bioceramics B.V. (HAp Granules, HAp Coating)
• SofSera Corporation (NanoXIM HAp, HAp Coating Powder)
• Fluidinova (nanoXIM CarePaste, nanoXIM FoodPaste)
• Berkeley Advanced Biomaterials (HAP-91, OsteoHAP)
• Taihei Chemical Industrial Co., Ltd. (TCP-HAp, HA-Fine Powder)
• SigmaGraft (PermaBone, PermaBlock)
• Bio-Rad Laboratories, Inc. (HAP Ceramic Hydroxyapatite, Macro-Prep Ceramic HAP)
• Merz North America, Inc. (Radiesse+, Radiesse Volume Advantage)
• Premier Biomaterials (Hydroxyapatite Microparticles, BoneGraft HAp)
• Himed (CAPTAL 60, CAPTAL 75)
• Nano Interface Technology (nHAp Powder, nHAp Dispersion)
• Sangi Co., Ltd. (NanoAmor, MedDent)
• Osartis GmbH (Osbone, Osbond)
• Zellwerk GmbH (HAp Scaffold, HAp Microsphres)
• Himed Japan Co., Ltd. (CAPTAL 50, CAPTAL 85)
• Medtronic (MasterGraft HAp, NanOss Bioactive)
• Collagen Matrix, Inc. (HydroxyMatrix, BoneGraftPlus)
• Kuros Biosciences (MagnetOs Granules, MagnetOs Putty)
• BioInteractions Ltd. (HAp BioCoat, HAp Antibacterial Coating)
• Xtant Medical (OsteoSponge HA, OsteoWrap HA)

Hydroxyapatite Market Report Scope:

Regulatory Reforms and Standards Fuel Hydroxyapatite Market Approvals and Innovation

• Over 180 hydroxyapatite-related patents were filed in the U.S. between 2022 and 2024, reflecting increased innovation in medical and cosmetic uses.
• In 2023, the FDA approved three new hydroxyapatite-based graft materials for orthopedic applications, boosting clinical adoption.
• The U.S. FDA updated its oral care guidelines in 2022 to allow clearer marketing claims for nano-hydroxyapatite in toothpaste formulations.
• Multiple companies adopted ISO 13779 standards for hydroxyapatite coatings on medical implants, streamlining product certifications.
• California implemented eco-compliance norms in 2023 that favor sustainable and synthetic hydroxyapatite production, supporting regulatory alignment with green manufacturing practices.

By Product, Nano-sized Segment Dominated the Hydroxyapatite Market in 2023 with a 55% Market Share

This dominance is driven by its superior surface area and bioactivity, which makes it ideal for high-performance dental and orthopedic applications. For instance, nano-hydroxyapatite is increasingly being used in toothpaste formulations like Boka and RiseWell, where it mimics natural enamel to aid remineralization. Additionally, orthopedic implant manufacturers are using nano-powders to coat prosthetics for better integration with bone tissues. Research published by the U.S. National Institutes of Health (NIH) in 2023 highlighted nano-hydroxyapatite’s improved osteoconductivity and enhanced antimicrobial resistance over micro-sized variants. Moreover, biomedical firms have started integrating nano-grade hydroxyapatite in 3D-printed bone scaffolds, which boosts regenerative potential. Companies like Bio-Rad and Berkeley Advanced Biomaterials are actively investing in nano-HAp tech to cater to growing demand in minimally invasive surgeries. These advantages, combined with increasing regulatory approvals and application breadth, cement nano-sized hydroxyapatite’s market leadership.

By End-Use Industry, Orthopedics Segment Dominated the Hydroxyapatite Market in 2023 with a 52% Market Share

This growth stems from the material’s excellent bone-bonding properties and rising demand for biocompatible implants. The U.S. Centers for Medicare & Medicaid Services (CMS) reported a surge in orthopedic procedures post-COVID-19, especially hip and knee replacements, which often utilize hydroxyapatite coatings. Major companies such as Stryker and Zimmer Biomet have integrated hydroxyapatite coatings into their joint replacement systems to improve fixation and longevity. Moreover, with the aging U.S. population, demand for bone void fillers and scaffolds has surged. The trend toward minimally invasive surgery has further elevated the need for advanced biomaterials like hydroxyapatite that ensure faster recovery and lower rejection risks. In addition, the Veterans Health Administration has been evaluating hydroxyapatite-based regenerative grafts in bone trauma cases, indicating broader public-sector adoption. These cumulative factors have fortified the dominance of the orthopedic end-use segment in the global hydroxyapatite market.

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Asia Pacific Dominated the Hydroxyapatite Market In 2023, Holding A 52% Market Share.

Asia Pacific leads the hydroxyapatite market due to its cost-effective manufacturing, growing healthcare investments, and strong regional demand. China reported a 15% increase in biomaterials production in 2023, with hydroxyapatite playing a key role. India’s expanding medical tourism has boosted use in implants, especially in orthopedics and dentistry. Japan’s Shiseido and Korea’s LG Household & Health Care have integrated hydroxyapatite in skincare, indicating trust in its safety and bio-affinity. Additionally, government incentives and low raw material costs support local production. These factors, combined with rising awareness of health and wellness, have firmly positioned Asia Pacific as a dominant force in the global hydroxyapatite market.

North America Emerged as the Fastest Growing Region in Hydroxyapatite Market with A Significant Growth Rate in The Forecast Period

North America's hydroxyapatite market is growing rapidly due to advanced biomaterials research, increased R&D funding, and regulatory support. The U.S. FDA’s fast-track approvals for hydroxyapatite-based dental and orthopedic products have spurred innovation. In 2023, Johnson & Johnson launched new bone fillers after spinal surgery success. The American Dental Association endorsed hydroxyapatite in pediatric toothpastes over fluoride for safety. Personalized healthcare trends and demand for natural, biocompatible materials are reshaping medical and cosmetic applications. Strong insurance coverage for implants and federal regenerative medicine funding further drive adoption. In Canada, growing biomedical research interest is supported by the Canadian Institutes of Health Research (CIHR). These developments collectively enhance North America's position as the fastest-growing hydroxyapatite market globally.

Recent Developments

• December 2024: Himalaya Wellness launched a peppermint-flavored Botanique Whitening+ toothpaste featuring hydroxyapatite for enamel protection and natural whitening benefits.
• June 2023: NSTDA and Chulalongkorn University introduced a nano-hydroxyapatite toothpaste for kids to support enamel remineralization and enhance dental health.

Table of Contents – Major Key Points

1. Introduction

2. Executive Summary

3. Research Methodology

4. Market Dynamics Impact Analysis

5. Statistical Insights and Trends Reporting

6. Competitive Landscape

7. Hydroxyapatite Market Segmentation, By Product

8. Hydroxyapatite Market Segmentation, By End Use Industry

9. Regional Analysis

10. Company Profiles

11. Use Cases and Best Practice

12. Conclusion

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