-- Development and Validation of an Assay to Detect the Loss of Function
Mutations in Filaggrin: Filaggrin is an important protein in the skin; when
there is a mutation in the filaggrin gene, the skin barrier can become
compromised. Patients with these mutations are more susceptible to atopic
dermatitis or eczema. These patients are also more susceptible to
complications associated with these diseases. ViraCor-IBT is the first lab
to develop a test that can detect six loss-of-function mutations in
Filaggrin. Previously, tests only recognized two mutations. The
presentation will cover how the lab developed and validated the test and
will take place at 2:45 p.m. on Sunday, November 8, 2009 during Concurrent
Session "C" in room B217-218.
-- Evaluation of Pneumococcal Antibody Avidity and Concentration in
Patients with Suspected Immunodeficiency: Assessment of patients with
recurrent infections for suspected immunodeficiency routinely involves the
use of vaccine challenge tests. This presentation will cover a new way to
evaluate the immune system so a physician can better determine if the
patient has mounted a significant response to the pneumococcal vaccine. The
presentation will take place at 2:15 p.m. on Monday, November 9, 2009
during Concurrent Session "C" in room B217-B218.
-- Development and Validation of a Test to Measure IgG Antibodies to the
IgE Receptor I Protein for Evaluation of Autoimmune Chronic Urticaria:
Approximately 35-50% of chronic urticaria (CU), or chronic hives, cases
have an autoimmune basis. Functional basophil-based histamine release
assays provide useful information on autoimmune CU, allowing physicians to
determine what antibody a patient has. This presentation will cover how
ViraCor-IBT's newly developed ELISA Binding assay may complement functional
CU assays with higher overall sensitivity for evaluating autoimmune CU. The
presentation will take place at 1:45 p.m. on Sunday, November 8, 2009
during Concurrent Session "C" in room B217-218.
-- Development and Validation of a T cell Activation Assay to Evaluate
Delayed (Type IV) Drug Hypersensitivity Reactions: Diagnosis of
hypersensitivity reactions to drugs is a major challenge in clinical
practice. This presentation will cover the development and validation of an
assay that will aid in the evaluation of patients who have suffered adverse
drug reactions, particularly skin reactions. The presentation will take
place at 1:30 p.m. on Sunday, November 8, 2009 during Concurrent Session
"B" in room B214-215.
-- Qualifications of T-Cell Excision Circles (TREC) for Diagnosis of
Immunodeficiency and Post-Bone Marrow Transplant Monitoring: This poster
will demonstrate how TREC can be quantified in bone marrow transplant
recipients. Quantification of TREC can provide useful information on T-cell
reconstruction and aid in the evaluation of newborns with recurrent
infections for suspected primary immunodeficiency.
For more information on ViraCor-IBT Laboratories and the company's testing
menu, please visit www.viracor-ibt.com.
About ViraCor-IBT Laboratories
ViraCor Laboratories and IBT Laboratories merged in June 2009 to form a
unique specialty diagnostics laboratory. The combined company specializes
in cellular, immunology, and allergy testing services as well as molecular
assays that detect and monitor microbial pathogens. The company serves
more than 4,000 physicians, hospitals, commercial laboratories and
biopharmaceutical companies nationwide. For more information, visit
www.viracor-ibt.com
Contact Information: ViraCor-IBT Media Contact: Amy Asper 615-327-7999 aasper@seigenthaler.com